International Journal of Pharmaceutical and Clinical Research

International Journal of Pharmaceutical and Clinical Research


International Journal of Pharmaceutical and Clinical Research
International Journal of Pharmaceutical and Clinical Research
2021, Vol. 3, Issue 1
Development and validation of quality-control determination for ciprofloxacin in appearance of ciprofloxacin degradation products using ciprofloxacin selective sensor

Amir Alhaj Sakur, Hashem A Dabbeet, Imad Noureldin

A PVC thin layer ciprofloxacin selective-electrodes was put together on account of Ciprofloxacin (CFX) examination proposes. The active material is CFX-tetradphenyl borate (CFX-TPB). Character description with analytical characteristic were concluded. Membrane plasticized using dioctylphthalate DOP. The put-together sensor has private reference Ag/AgCl sensor. Also, sensor has external reference sensor. The sensor exhibits an intimate Nernst slop in case of CFX-TPB percentage inside membrane was 7%. The electrode presented a quick response reached 9±1 seconds for an age of 384 hours of work without considerable alter in electrode parameters. In a ranges 2-6 for pH. The method occupied validation concerning selectivity, precision, Recovery, linearity, and limit of detection (LOD). of Results analysis based on statistic for submitted and comparison way applying variance ratio and Students were put into practice and so gave no consequential distinction between the methods respecting precision and accuracy, correspondingly. The sensor has been used as a Quality-Control indicator for direct definition of CFX putting in consideration attendance of its degradation materials (Desfluoro compound, Ethylenediamine analogue, Descarboxy analogue, Chloro analogue) in Ciprofloxacin tabs. go together with RSD smaller than 2% which point out decent precision, and likewise in absolute solutions against median recovery 99.99%, and a median RSD of 0.04% in case of 1 m.Mol.
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How to cite this article:
Amir Alhaj Sakur, Hashem A Dabbeet, Imad Noureldin. Development and validation of quality-control determination for ciprofloxacin in appearance of ciprofloxacin degradation products using ciprofloxacin selective sensor. International Journal of Pharmaceutical and Clinical Research, Volume 3, Issue 1, 2021, Pages 26-32
International Journal of Pharmaceutical and Clinical Research International Journal of Pharmaceutical and Clinical Research