In this review article we have discussed about the natural antioxidant used in Parkinson disease. Parkinson disease is a second most common neurodegenerative disorder after Alzheimer’s disease. The aetiology of the disease in most patients is unknown, but different genetic causes have been identified. Although familial forms of PD account for only 5%–15% of cases, studies on these families provided interesting insight on the genetics and the pathogenesis of the disease allowing the identification of genes implicated in its pathogenesis and offering critical insights into the mechanisms of disease. The cardinal motor symptoms of PD are tremor, rigidity, bradykinesia/akinesia and postural instability, PD is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by accumulation of misfolded α-synuclein, which is found in intra-cytoplasmic inclusions called Lewy bodies. Some natural antioxidants used for curing PD are- Uncaria rhynchophylla, Nardostachys jatamans, Chrysanthemuum morifolium Ramat etc.