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International Journal of Pharmaceutical and Clinical Research

Vol. 4, Issue 2, Part A (2022)

Theoretical study of synthesis and pharmaceutical activity of 1, 3, 4-oxadiazole derivatives

Author(s):

Muntaha Yaseen Hayal, Farqad M Baqer and Bassam A Hassan

Abstract:

Heterocyclic compounds with five members and 2 nitrogen and one oxygen atoms make up oxyadiazoles. Ring condensation and rearrangement processes are used to create them. One oxygen atom and two nitrogen atoms make up the five-membered circle of the heterocyclic compound 1, 3, 4-oxadiazole (1). It is made by substituting two nitrogen atoms of the pyridine type (- N=) for two of the methyl molecules in furan. The three identified isomers are 1, 2, 4-oxadiazole, 1, 2, 3-oxadiazole, and 1, 2, 5-oxadiazole. both the 1, 2, 4- and 1, 3, 4-oxadiazole, Activity against fungi and bacteria Using amoxicillin as the standard gold medication, all the synthesized compounds were tested for their bactericidal activity against Staphylococcus (MMTCC 96), Bacillus subtilis (MTCC 441), Pseudomonas aeruginosaa (MTCC 1688), and Escherichias colii (MTCC 443).

Pages: 06-10  |  536 Views  204 Downloads


International Journal of Pharmaceutical and Clinical Research
How to cite this article:
Muntaha Yaseen Hayal, Farqad M Baqer and Bassam A Hassan. Theoretical study of synthesis and pharmaceutical activity of 1, 3, 4-oxadiazole derivatives. Int. J. Pharm. Clin. Res. 2022;4(2):06-10. DOI: 10.33545/26647591.2022.v4.i2a.33
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