Vol. 6, Issue 1, Part A (2024)

Dementia presents a significant public health challenge, with profound implications for affected individuals, families, and healthcare systems. Despite extensive research efforts, effective treatments to halt or reverse the progression of dementia remain elusive. Neurocognitive enhancers have emerged as a promising therapeutic approach to mitigate cognitive decline and improve quality of life for individuals with dementia. This comprehensive review examines the role of neurocognitive enhancers in dementia, focusing on pharmacological agents targeting various neurotransmitter systems and synaptic function. The review discusses the mechanisms of action, efficacy, safety profiles, and clinical use of neurocognitive enhancers, drawing insights from key clinical trials and studies. Additionally, the review explores challenges, limitations, and future directions in the field of neurocognitive enhancement for dementia care. By synthesizing evidence and providing critical analysis, this review aims to inform clinical practice, stimulate further research, and advance the management of dementia.