Vol. 6, Issue 1, Part A (2024)

Annona squamosa L. (custard apple) belonging to family Annonaceae.

The Research and application of plants in food appendix and drugs have attracted great curiosity. This study aimed to examine the capability of several solvents for the cognizance of the main compounds from Annona squamosa leaves and to evaluate the Antibacterial, Antioxidant, and anticancer activities of these extracts.

Methods: Gas chromatography-mass spectroscopy was used to screen the bioactive compounds of a squamosa methanolic extract. The free radical, hydrogen peroxide, and nitric oxide scavenging activities of the extracts were investigated. furthermore, MTT, nuclear staining, LDH, and monolayer wound repair assays were performed to evaluate the potential anticancer activity was tested by using a well diffusion assay.

Conclusion: Major bioactive components found in squamoa leaves have been shown to inhibit the growth of numerous types of bacteria and colon cancer cell lines. This has shown the effectiveness of squamosa leaves as an alternative source of antibiotics and for the creation of new medications for the treatment of colon cancer.