Vol. 6, Issue 2, Part A (2024)

Plants as medicines are still the mainstay of health care in several developing as well as under developing countries. People mostly rely on local herbs for food and cure of different ailments. Tragia plukenetii and Tragia involucrata (Euphorbiaceae) used in treating various ailments of human. The study aims to evaluate the diuretic effect of ethanolic extract of Tragia plukenetii and Tragia involucrata using animal models. To evaluate the diuretic activity of the selected plants, Albino rats were divided into four groups of six animals each. The control group received normal saline, the reference group received furosemide and the test groups were administered ethanolic extracts by intra-peritoneal route, respectively. Significant diuretic effects were recorded in the treated groups in a dose dependent manner. The plant extracts enhanced the excretion of sodium and potassium ions were significantly. Further studies are encouraged to isolate the pure bioactive compounds responsible for diuretic activity.