Vol. 6, Issue 2, Part A (2024)

The integration of Quality by Design (QbD) principles in the formulation and development of topical delivery systems represents a significant advancement in pharmaceutical sciences, particularly for enhancing the efficacy and safety of active ingredients. This study applies Quality by Design (QbD) principles to develop a nanosponges gel system incorporating Hydroquinone and Salicylic Acid for skin lightening and acne treatment. Nanosponges enhance drug stability, control release, and improve skin permeation. Using Design of Experiments (DoE), key formulation parameters such as polymer concentration, surfactant type, and drug load were optimized. The gel was tested for particle size, zeta potential, drug entrapment, and release profiles, with stability and efficacy assessed in real-world conditions. The QbD approach successfully produced a stable, efficient formulation, demonstrating its value in advancing topical drug development.