Vol. 7, Issue 2, Part A (2025)

Liver has a crucial role in the human body. It has multiple functions like bile production and metabolism, carbohydrate metabolism, storehouse of several vitamins and minerals, detoxification and many more. Liver disease is responsible for more than two million deaths each year, including those caused by cirrhosis, viral hepatitis, and liver cancer. It accounts for 4% of all global deaths, meaning 1 in every 25 deaths. Additionally, one-third of liver-related deaths occur in women. NAFLD is a condition characterized by excessive fat build up in liver leads to steatosis, fibrosis, cirrhosis and even liver cancer. It is closely associated with obesity, metabolic syndrome, and poor dietary habits. Dietary fat quality, not just quantity, plays a crucial role in NAFLD pathogenesis and progression. This review evaluates the role of various nuts and seed oils walnut, sesame, cottonseed, hemp seed, olive, and wheat germ oil—in mitigating hepatic steatosis and inflammation. Each oil offers distinct bioactive compounds and fatty acid profiles contributing to their hepatoprotective effects. In this review, we have seen different nuts and seeds oils, there bioactivity, antioxidant activity, and that how the right choice of oil can help in liver disease. Overall, these oils show promise in NAFLD prevention and management, primarily through lipid modulation, oxidative stress reduction, and anti-inflammatory actions. However, limitations such as the paucity of large-scale human trials and heterogeneity in study protocols call for further clinical research. This paper supports the incorporation of specific dietary oils as part of comprehensive lifestyle interventions for NAFLD management and highlights the potential of seed oils as nutraceutical agents.