Vol. 7, Issue 2, Part B (2025)

The central nervous system disorders have always been a mystery and remain as a challenge in presence of the blood brain barrier. The presence of BBB restricts the entry of external material including medicines into the brain tissue. The present day’s advancement in the drug delivery system is trying to overcome the limited therapeutic effect imposed by the blood brain barrier. In the present scenario the intranasal route has emerged as the promising resolution for the delivery of drug to overcome the barrier. The utilization of lipid based nanoparticles like micro emulsions, nano-structured lipid carriers, liposomes, and solid lipid nanoparticles helps in achieving the enhancement in efficacy of nose to brain delivery. This is being made possible by increasing the drug absorption from the nasal membrane through nano particles. Moreover, in situ gel system have extended the retention time of the administered drug within the nasal cavity for prolonged therapeutic effect. Additionally combining the in situ gel system with the lipid based nano particles results in synergistic effect with overall enhancement of efficacy. The present review work focuses on the importance of nasal drug delivery system in treatment of CNS related disorders.