Vol. 8, Issue 1, Part A (2026)

Background: Male sexual dysfunction encompasses a range of illnesses that impair sexual function, including erectile dysfunction (ED), Peyronie's disease (PD), and premature ejaculation (PE). Over 50% of men aged 40 to 70 report experiencing some degree of erectile dysfunction, indicating a significant prevalence that increases with age. Age, diabetes mellitus, cancer, stroke, hypertension, penile trauma, depression, anxiety, and disruptions in central serotonin neurotransmission and 5-HT postsynaptic receptor functionality are risk factors for male sexual dysfunction. The International Index of Erectile Dysfunction, the Sexual Health Inventory for Men, and the Premature Ejaculation Diagnostic Tool are three questionnaires utilised for screening these conditions. The fruits of C. carandas are acknowledged for their efficacy in alleviating haemorrhoids, appetite loss, nerve disorders, oedema, colic, splenomegaly, hepatomegaly, amenorrhoea, cardiovascular illnesses, cerebral anorexia in humans, and for treating fever. It is employed in the management of epilepsy, diarrhoea, canine bites, myopathic spasms, coughs and colds, leprosy, itch, inflammation, malaria, and dermal infections.

Method: The purpose of the current study was to assess the efficiency of bioactive found in C. carandas for their inhibitory influence on PDE-5 enzyme to elicit the aphrodisiac potency. The Auto Dock software used a grid-based docking algorithm to determine the bond.

Result: C. carandas fruit found to be effective aphrodisiac agent and effectively binds to be target protein PDE-5 with binding energy of -10.92 & -8.55 kcal/mol for β-sitosterol and lupeol respectively.

Conclusion: The outcome of findings revealed that phytosterol and triterpenoid showed potent inhibitory effect on PDE-5 enzyme which reflects the efficacy of C. carandas fruit as potent aphrodisiac agent.